Sulphadiazine in the Treatment of Cholera

was shorter than that of the controls (7.1 days) and the total amount of saline required was less in the sulphadiazine-treated cases than in the controls. Chu, Huang, Chang arid Kao (1946) report the treatment of 25 cases of cholera with sulphadiazine and compare the result with that of 29 cases not treated with sulphadiazine and claim efficiency for sulphadiazine on clinical data. The results of treating a larger series of cholera patients with sulphadiazine* as compared with the results of a parallel series not treated with sulphadiazine are presented in table I. All the patients were suffering clinically from cholera and were treated as in-patients in a cholera hospital. The selection of cases for treatment was made on alternate admission basis. In many, the diagnosis was confirmed by the isolation of agglutinable vibrios, but it was not possible to make full bacteriological examination in every case. All the patients received the usual saline supportive treatment: The sulphadiazine series received powdered sulphadiazine 1 gramme, 4-hourly during the acute stage of the disease and three times a day for two days afterwards unless the patient left the hospital earlier.